Ideas never die. Ideas live forever. Once the germ of an idea is born..it remains. So is quality also an idea ? Is quality a thought ? or attitude ? or pursuit for excellence ? whatever it is, but why it is what it is. The philosophical debate on quality will continue. It will give many answers which may or may not fit best to the question that what quality is!
I remember entering the room of a Manager of one pharma company which was tidy, neat and well maintained. The placement of pens and pencils in the pen holder, colours, sketch pens, books, charts and chair - in fact everything was wonderful. Or did I only think that was wonderful ? My attitude or his attitude ?
Alfred Nobel, so distress from his invention of dynamite, raised his wealth for an award - Nobel prize. He thought rather unusual - a quality thought? Does thoughts also have quality ?
But had he never had so much of wealth to offer, what Alfred would have done?? No money - no award. The quality of Life...
You never know - quality is multidimensional, multifaceted, omnipresent and mysteriously hidden in the seed of human thoughts - human thought which have the courage to raise this civilization! Is it?
Is quality an Idea ?
Wednesday, April 30, 2008
Saturday, April 5, 2008
Column Equivalency Tool at USP
Vishwanath in the Pharmaceutical Discussion Forum, informs the new wonder from USP. The USP has recently launched a Column Equivalency tool on it's web-site - This is an interactive aid that assists user in finding a ‘Possible Alternative Column' to the Column used in development & Validation of a certain Chromatographic Procedure.
The USP procedure uses the parity among the parameters like CTF (Chelating Tailing Factor); CFA (Capacity Factor Amitryptiline); TFA (Tailing Factor Amitryptiline) & BD (Bonding Density) to arrive at the possible alternatives;
PQRI uses the comparison of Column hydrophobicity (H); Column Steric Interaction (S); Column Hydrogen-bond Acidity (A); Column Hydrogen-Bond Basicity (B) & Column Ion-Exchange Capacity (C) as the basis for calculating equivalence
The USP Column listing is essentially the compendial columns (listed in USP-NF) - whereas the PQRI listing is bigger & not specific to compendial columns..
To accessed the toold, click here (both USP & PQRI column listings)
The USP procedure uses the parity among the parameters like CTF (Chelating Tailing Factor); CFA (Capacity Factor Amitryptiline); TFA (Tailing Factor Amitryptiline) & BD (Bonding Density) to arrive at the possible alternatives;
PQRI uses the comparison of Column hydrophobicity (H); Column Steric Interaction (S); Column Hydrogen-bond Acidity (A); Column Hydrogen-Bond Basicity (B) & Column Ion-Exchange Capacity (C) as the basis for calculating equivalence
The USP Column listing is essentially the compendial columns (listed in USP-NF) - whereas the PQRI listing is bigger & not specific to compendial columns..
To accessed the toold, click here (both USP & PQRI column listings)
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